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Cell Reports published the latest research of Prof. Cheguo Cai's team as cover article
?On Sep 13 2022, a research team led by Prof. CAl Cheguo, Medical Research Institute and Frontier Science Center for lmmunology and Metabolism of Wuhan University, just made progress in mammary stem cell (MaSC) and triple negative breast cancer (TNBC) research.Their work, “CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression”, published...
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New study from Prof. Haojian Zhang's laboratory reveals an important role of YBX1 in acute myeloid leukemia
?On March 24, 2021, the international renowned journal BLOOD published an article entitled "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner", reported the molecular mechanism of YBX1 in selectively regulating the survival of myeloid leukemia cells. This work came from Dr. Haojian Zhang’s laboratory. Dr. Zhang is a profess...
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Jiang, W.#, Zhang, M.#, Gao, C.#, Yan, C., Gao, R., He, Z., Wei, X., Xiong, J., Ruan, Z., Yang, Q., Li, J., Li, Q., Zhong, Z., Zhang, M., Yuan, Q., Hu, H., Wang, S., Hu, M. M., Cai, C., Wu, G. S., Jiang, C., Zhang, Y.L., Zhang, C.S., Zhang, J.* (2023). A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress. EMBO J e113743.（张静）?AbstractMitochondria ...
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An, J.#, Zhang, C.P.#, Qiu, H.Y.#, Zhang, H.X.#, Chen, Q.B., Zhang, Y.M., Lei, X.L., Zhang, C.X., Yin, H.*, and Zhang, Y.* (2023). Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway. Nat Biomed Eng 10.1038/s41551-023-01073-7.（殷昊、张楹）?AbstractViral delivery of DNA for the targeted reprogramming of human T cells can lead to ...
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Yi, Y., Lan, X., Li, Y., Yan, C., Lv, J., Zhang, T., and Jiang, W.* (2023). Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation. Dev Cell S1534-5807(23)00335-0.（蒋卫）?AbstractMetabolic remodeling is one of the earliest events that occur during cell differentiation. Here, we define fatty acid metabolism as a key player ...
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Zhang, L.#, Jiang, C.#, Zhong, Y., Sun, K., Jing, H., Song, J., Xie, J., Zhou, Y., Tian, M., Zhang, C., Sun, X., Wang, S., Cheng, X., Zhang, Y., Wei, W., Li, X., Fu, B., Feng, P., Wu, B., Shu, H.B., Zhang, J.* (2023). STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2. Nat Cell Biol 10.1038/s41556-023-01185-x.（张军杰）?AbstractEvasion of antitumour immunity ...
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Peng, Q.#, Shi, X.#, Li, D., Guo, J., Zhang, X., Zhang, X., & Chen, Q.* (2023). SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability. Cell Death Differ 30(7), 1849–1867.（陈强）?AbstractSCML2 has been found to be highly expressed in various tumors. However, the extent to which SCML2 is involved in tumorigenesis and cancer therapy is yet to be fully understood....
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?Li, Y., Zhou, X., Cheng, C., Ding, G., Zhao, P., Tan, K., Chen, L., Perrimon, N., Veenstra, J. A., Zhang, L., & Song, W.* (2023). Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila. Cell discov, 9(1), 49.（宋威）?AbstractSevere sleep deprivation (SD) has been highly associated with systemic energy wasting, such as lipid loss and glycogen depletion. Despite immune dysregu...
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