bv1946备用网址

科研队伍
张好建

 

 最后学位:哲学博士(Ph.D.,   University of Massachusetts Medical School

 职称职务:教授

 专业方向:细胞生物学

 研究方向:造血发育与血液疾。槐砉圩嫉骺兀恢琢雒庖

 电话号码:027-68750365

 电子邮件:Haojian_Zhang@whu.edu.cn


教育经历    

1997-2001  山东师范大学生物系生命科学专业, 学士    

2001-2004  中科院动物所细胞生物学专业, 硕士    

2006-2008   美国杰克逊研究所分子细胞生物学专业, 博士研究生    

2008-2012   美国麻萨诸塞大学医学院肿瘤生物学专业,博士    

                   

工作经历与任职    

2004-2006 中科院上海药物所,研究助理        

2012-2016 美国Dana Farber肿瘤研究所,哈佛医学院,Research Fellow

2016-至今 bv1946备用网址,教授    

         

获奖情况        

2013-2016 美国Leukemia Lymphoma Society Fellow奖      

2016   哈佛大学华人学者生命科学杰出研究奖    

           

代表性论文          

1. Rong Yin#, Jiwei Chang#, Yashu Li#, Zhuying Gao, Qiang Qiu, Qifan Wang, Guoqiang Han, Jihua Chai, Mengdie Feng, Peipei Wang, Tiantian Zhang, Xueqin Xie, Jin Hu, Ying Cheng, Chengli Guo, Jing Wang, Kexin Gao, Manman Cui, Shaoguang Li, Yuhuan Zheng, Wei Jiang, Yiguo Hu, Qing-yong Yang, Haojian Zhang*. Landscape of RNA m6A modification across hematopoietic hierarchy unveils an essential role of IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell, 2021, Oct. 21

2. Mengdie Feng#; Xueqin Xie#; Guoqiang Han#; Tiantian Zhang; Yashu Li; Yicun Li; Rong Yin; Qifan Wang; Tong Zhang; Peipei Wang; Jin Hu; Ying Cheng; Zhuying Gao; Jing Wang; Jiwei Chang; Manman Cui; Kexin Gao; Jihua Chai; Weidong Liu; Chengli Guo; Shaoguang Li; Lingbo Liu; Fuling Zhou; Jianjun Chen; Haojian Zhang*. YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner, Blood, 2021, 138:71-85.

3. Jiazhen Wang#; Yicun Li#; Peipei Wang#; Guoqiang Han#; Tiantian Zhang; Jiwei Chang; Rong Yin; Yi Shan; Jin Wen; Xueqin Xie; Mengdie Feng; Qifan Wang; Jin Hu; Ying Cheng; Tong Zhang; Yashu Li; Zhuying Gao; Chengli Guo; Jing Wang; Jianfei Liang; Manman Cui; Kexin Gao; Jihua Chai; Weidong Liu; Hui Cheng; Lei Li; Fuling Zhou; Lingbo Liu; Yi Luo; Shaoguang Li; Haojian Zhang*. Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis, Cell Stem Cell, 2020, 27: 81-97.

4. Haojian Zhang; David E. Kozono; Kevin W. O’Connor; Sofia Vidal-Cardenas; Alix Rousseau; Abigail Hamilton; Lisa Moreau; Emily F Gaudiano; Joel Greenberger; Grover Bagby; Jean Soulier; Markus Grompe; Kalindi Parmar; Alan D. D’Andrea*. TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia, Cell Stem Cell, 2016, 18:668-681.

5. Haojian Zhang; Cong Peng; Yiguo Hu; Huawei Li; Zhi Sheng; Yaoyu Chen; Con Sullivan; Jan Cerny; Lloyd Hutchinson; Anne Higgins; Patricia Miron; Xueqing Zhang; Michael A Brehm; Dongguang Li; Michael R Green; Shaoguang Li*. The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Nature Genetics, 2012, 44: 861-871.

6.  Zhang H, Li S. Molecular Mechanisms for survival regulation of chronic myeloid leukemia stem cells. Protein Cell. 2013, 4:186-196.    

7.Yang Z, Zhang H, Ma L, Peng C, Chen Y, Wang J, Green M, Li S, Rosmarin A. Transcriptional factor GABP is required for hematopoietic stem cell cycling and development of chronic myeloid leukemia through regulating PRKD2 kinase. PNAS, 2013, 110: 2312-7.

8.  Haojian Zhang; Huawei Li; Hualin Xi; Shaoguang Li*. HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells, Blood, 2012, 119: 2595-2607.

9. Zhang H, Li H, Ho N, Li D, Li S. Scd1 plays a tumor suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia. Mol. Cell. Biol. 2012, 32:1776-1787.    

10.  Chen Y, Hu Y, Zhang H, Peng C, Li S. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nature Genetics. 2009, 41: 783-792.


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