bv1946备用网址

科研队伍
姜恺

 

 最后学位:理学博士(PhD,中国科学技术大学)

 职称职务:教授、博导

 专业方向:细胞生物学、生物化学、生物物理学

 研究方向:细胞骨架与细胞周期

 电话号码:027-68758602

 电子邮件:jiangkai@whu.edu.cn

 

教育经历

1999-2003 中国科学技术大学  学士

2003-2009 中国科学技术大学  博士

 

工作经历与任职

2009-2010 荷兰伊拉斯谟医学中心(Erasmus Medical Center) 博士后

2011-2017 荷兰乌特勒支大学(Utrecht University) 博士后

2017-至今 bv1946备用网址  教授

 

代表性论文

1. Huang, J., Liang, Z., Guan, C., Hua, S., and Jiang, K. (2021). WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin. J Cell Biol. 220.

2. Hua, S., and Jiang, K. (2020). Expression and Purification of Microtubule-Associated Proteins from HEK293T Cells for In Vitro Reconstitution. Methods Mol Biol. 2101:19-26.

3. Jiang, K.*#, Rezabkova, L.*, Hua, S., Liu, Q., Capitani, G., Altelaar, A.F.M., Heck, A.J.R., Kammerer, R.A.#, Steinmetz, M.O.#, and Akhmanova, A.# (2017). Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat Cell Biol 19, 480-492. (*Co-first author, #Co-corresponding author)

4. Atherton, J.*, Jiang, K.*, Stangier, M.M., Luo, Y., Hua, S., Houben, K., van Hooff, J.J.E., Joseph, A.P., Scarabelli, G., Grant, B.J., Roberts, A.J., Topf, M., Steinmetz, M.O., Baldus, M., Moores, C.A., and Akhmanova, A. (2017). A structural model for microtubule minus-end recognition and protection by CAMSAP proteins. Nat Struct Mol Biol 24, 931-943.

5. Jiang, K., Hua, S., Mohan, R., Grigoriev, I., Yau, K.W., Liu, Q., Katrukha, E.A., Altelaar, A.F., Heck, A.J., Hoogenraad, C.C., and Akhmanova, A. (2014). Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. Dev Cell 28, 295-309.

6. Jiang, K., Toedt, G., Montenegro Gouveia, S., Davey, N.E., Hua, S., van der Vaart, B., Grigoriev, I., Larsen, J., Pedersen, L.B., Bezstarosti, K., Lince-Faria, M., Demmers, J., Steinmetz, M.O., Gibson, T.J., and Akhmanova, A. (2012). A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins. Curr Biol 22, 1800-1807.

7. Jiang, K., and Akhmanova, A. (2011). Microtubule tip-interacting proteins: a view from both ends. Curr Opin Cell Biol 23, 94-101.

8. Jiang, K., Wang, J., Liu, J., Ward, T., Wordeman, L., Davidson, A., Wang, F., and Yao, X. (2009). TIP150 interacts with and targets MCAK at the microtubule plus ends. EMBO Rep 10, 857-865.

9. Faltova, L.*, Jiang, K.*, Frey, D., Wu, Y., Capitani, G., Prota, A.E., Akhmanova, A., Steinmetz, M.O., and Kammerer, R.A. (2019). Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex. Structure 27, 1375-1383 e1373.

10. Jiang, K.*, Faltova, L.*, Hua, S., Capitani, G., Prota, A.E., Landgraf, C., Volkmer, R., Kammerer, R.A., Steinmetz, M.O., and Akhmanova, A. (2018). Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex. Structure 26, 375-382 e374.


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