bv1946备用网址

科研队伍
崔逸仙

 

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 最后学位:理学博士(PhD,清华大学)

 职称职务:教授、博导

 专业方向:细胞生物学

 研究方向:细胞自噬与人类疾病

 电话号码:027-87267099

 电子邮件:yixian.cui@whu.edu.cn


教育经历

2003-2007 湖南大学  生命科学与技术学院 学士

2007-2013 清华大学  生命科学学院    博士


工作经历与任职

2013-2015 清华大学                 博士后

2015-2019 美国加州大学圣地亚哥分校         博士后及助理项目科学家

2019-至今 bv1946备用网址/免疫与代谢前沿科学中心 教授

     bv1946备用网址中南医院             特聘教授


所获研究资助

国家自然科学基金面上项目(2021-2024,主持)

bv1946备用网址双一流建设专项人才启动经费(2020-2022,主持)

国家自然科学基金青年科学基金项目 (2014-2016,主持)

 

研究领域

  本课题组主要从事细胞自噬的分子机制及其与人类疾病关系的研究。运用酵母,哺乳动物细胞和果蝇为模型;细胞生物学、分子生物学、生物化学及遗传学手段来研究细胞自噬(主要是内质网选择性自噬)的分子机制,及其与人类疾。ㄖ饕巧窬诵行约膊。┑墓叵。


代表性论文

1. Yixian Cui, Smriti Parashar, Muhammad Zahoor, Patrick G. Needham, Muriel Mari, Ming Zhu, Shuliang Chen, Hsuan-Chung Ho, Fulvio Reggiori, Hesso Farhan, Jeffrey L. Brodsky, and Susan Ferro-Novick*. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science 365, 53 –60, 2019;

2. Yixian Cui, Smriti Parashar, and Susan Ferro-Novick*. A new role for a COPII cargo adaptor in autophagy. Autophagy Dec 3:1-3, 2019;

3. Lingang He, Xuehong Qian, Yixian Cui*. Advances in ER-phagy and its diseases relevance. Cells 10(9):2328, 2021;

4. huliang Chen, Yixian Cui, Smriti Parashar, Peter J. Novick*, and Susan Ferro-Novick*. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A 115(27), E6237-E6244, 2018;

5. Shuliang Chen, Muriel Mari, Smriti Parashar, Dongmei Liu, Yixian Cui, Fulvio Reggiori, Peter J. Novick*, Susan Ferro-Novick*. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Proc Natl Acad Sci U S A 117(31), 18530-18539, 2020;

6. Yixian Cui*#, Shanke Zhao#, Xudong Wang, Bing Zhou*. A novel Drosophila mitochondrial carrier protein acts as a Mg2+ exporter in fine-tuning mitochondrial Mg2+ homeostasis. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research 1863, 30–39, 2016 (co-first author and co-corresponding author);

7. Yixian Cui*#, Shanke Zhao#, Juan Wang, Xudong Wang, Bingquan Gao, Qiangwang Fan, Fei Sun, Bing Zhou*. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research 1853, 724–732, 2015 (co-first author and co-corresponding author);

8. Yixian Cui, Shanke Zhao, Zhihao Wu, Pinghua Dai, Bing Zhou*. Mitochondrial release of the NADH dehydrogenase Ndi1 induces apoptosis in yeast. Molecular Biology of the Cell 23, 22, 4373-4382, 2012;

9. Lan Wang, Qian Liu, Jinchun Chen, Yixian Cui, Bing Zhou, Yongxiang Chen, Yufen Zhao, Yanmei Li *. Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides' connection with antimicrobial peptides. Biological Chemistry 393, 7, 641-646, 2012.


课题组长期招收博士后及科研助理,也热情欢迎研究生及本科生加盟。

 

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